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Ethnikis Antistaseos 51-53, Kalamaria, Thessaloniki

CARILLON trial for patients with functional mitral regurgitation in heart failure

The Heart Center team participates various multicenter International randomized trials. The main focus of the research is percutaneous treatment of mitral regurgitation. After completing the initial phase of  RESHAPE HF-2 trial having recruited 105 patients, the team has initiated the  CARILLON pivotal trial randomizing patients with functional mitral regurgitation and heart failure to conservative medical treatment vs implantation of CARILLON device.

The heart team of Heart Center which is based in the  European Interbalkan Medical Center in Thessaloniki is currently the only institution in Greece that participates in this trial. Recruitment in participation of patients in the trial is totally free of charge.

Currently the heart center team are currently the top recruiters internationally for this trial having already recruited 15 patients.

The Carillon implantation aims to reduce functional mitral regurgitation in patients with heart failure. The aim of the trial is to look for hard and points such as reduction in  mortality and hospitalization in these patients. Carillon  device is currently CE Mark approved and globally over 1,000 procedures have been performed with good results.

The screening data of the patients are sent to the Cleveland clinic Echo core lab and after approval the patients are randomized to eitherreceiving the device versus continuing on medical treatment. The patients are being followed up for a period of 5 years by the Heart Center team.

The screening the follow-up and the procedure itself are totally free of charge.
Currently in the CARILLON N trial several hospitals participate internationally such as:

European Interbalkan Medical Center

Cleveland Clinic

Ochsner Health System

Dignity Health Mercy Gilbert and Chandler

Northshore University HealthSystem



Henrico Doctors/Sarah Cannon Research Institute

Delray Medical Center

Vassar Brothers Medical Center

Telephone for participation in the trial: (+30) 2310400929

Καρδιολογικό Κέντρο στη Θεσσαλονίκη